Nonlinear Mixed Effects Classes And Methods For S
نویسندگان
چکیده
We describe extensions to the nonlinear modeling facilities in release 3 of S and Splus. These extensions provide classesand methods for fitting and analyzing nonlinear mixed effects models with the two-stage estimation method described by Lindstrom and Bates (1990). They are implemented in a combination of S and C code and complement the classes and methods for the linear mixed effects model that we previously contributed to the StatLib collection. These methods include an implementation of the “loose-coupling” approach to the pseudo-data step which reduces the overall computational burden in problems with many clusters.
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